S. N. Loh

Mimicking Kidney Flow Shear Efficiently Induces Aggregation of LECT2, a Protein Involved in Renal Amyloidosis

This study shows that kidney-like flow shear in microfluidic devices efficiently induces LECT2 aggregation, with the I40V mutation enhancing fibril formation and aggregate size.

A Generalizable Nanopore Sensor for Highly Specific Protein Detection at Single-Molecule Precision

This paper introduces a nanopore sensor for specific protein detection without steric hindrance, validated across diverse proteins with unique electrical signatures.

An adaptable, monobody-based biosensor scaffold with FRET output

The paper describes a monobody-based biosensor scaffold that uses FRET to detect ligand binding, demonstrating its versatility for creating fluorescent biosensors for multiple targets.

Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D

This study identifies the N-terminal domain (NTD) of p53 as the major binding site for Cyclophilin D, revealing dynamic electrostatic interactions and a minimal binding region for mPTP regulation.

Mechanistic insights into the enhancement or inhibition of phase separation by polyubiquitin chains of different lengths or linkages

This study investigates how different polyubiquitin chain lengths and linkages affect UBQLN2's liquid-liquid phase separation, showing that extended chains enhance while compact chains inhibit it.

Engineering A Fluorescent Protein Color Switch Using Entropy-driven Beta Strand Exchange

The paper designs a fluorescent protein color switch that changes from green to yellow upon ligand binding, using a conformational mechanism based on beta strand exchange.

Zinc shapes the folding landscape of p53 and establishes a new pathway for reactivating structurally diverse p53 mutants

This paper develops a thermodynamic model to analyze how p53 mutations affect zinc binding and stability, showing that synthetic zinc metallochaperones can reactivate diverse p53 mutants.