Author

J.-H. Ha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

S. N. Loh· 5 shared H. Sekhon· 2 shared A. J. Blayney· 1 shared A. J. Wolfe· 1 shared A. M. John· 1 shared A. R. Blanden· 1 shared C. Demas· 1 shared D. R. Carpizo· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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5 shared papersBiochemistry

S. N. Loh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Mimicking Kidney Flow Shear Efficiently Induces Aggregation of LECT2, a Protein Involved in Renal Amyloidosis

J.-H. Ha, Y. Xu, H. Sekhon, S. Wilkens, D. Ren, S. N. Loh

This study shows that kidney-like flow shear in microfluidic devices efficiently induces LECT2 aggregation, with the I40V mutation enhancing fibril formation and aggregate size.

bioRxiv · Jul 13, 2023Biochemistry

A Generalizable Nanopore Sensor for Highly Specific Protein Detection at Single-Molecule Precision

M. Ahmad, J.-H. Ha, L. Mayse, M. Presti, A. J. Wolfe, K. J. Moody, S. N. Loh, L. Movileanu

This paper introduces a nanopore sensor for specific protein detection without steric hindrance, validated across diverse proteins with unique electrical signatures.

bioRxiv · Oct 12, 2022 · PreprintBiophysics

An adaptable, monobody-based biosensor scaffold with FRET output

M. F. Presti, J.-H. Ha, S. N. Loh

The paper describes a monobody-based biosensor scaffold that uses FRET to detect ligand binding, demonstrating its versatility for creating fluorescent biosensors for multiple targets.

bioRxiv · Aug 26, 2022 · PreprintBiochemistry

Ultramicrobacteria in various fermented cabbages

H.-W. Lee, S.-R. Yoon, Y.-M. Dang, M. Kang, K. H. Lee, J.-H. Ha, J.-W. Bae

This study identifies ultramicrobacteria in fermented cabbages using advanced sequencing and microscopy, revealing their diversity and potential ecological significance.

bioRxiv · Jan 26, 2022 · PreprintMicrobiology

Engineering A Fluorescent Protein Color Switch Using Entropy-driven Beta Strand Exchange

A. M. John, H. Sekhon, J.-H. Ha, S. N. Loh

The paper designs a fluorescent protein color switch that changes from green to yellow upon ligand binding, using a conformational mechanism based on beta strand exchange.

bioRxiv · Oct 20, 2021 · PreprintBiophysics

Zinc shapes the folding landscape of p53 and establishes a new pathway for reactivating structurally diverse p53 mutants

A. R. Blanden, X. Yu, A. J. Blayney, C. Demas, J.-H. Ha, Y. Liu, T. Withers, D. R. Carpizo, S. N. Loh

This paper develops a thermodynamic model to analyze how p53 mutations affect zinc binding and stability, showing that synthetic zinc metallochaperones can reactivate diverse p53 mutants.

bioRxiv · Jul 23, 2020Biochemistry