Author

V. Balachandran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Beck· 1 shared A. Cardenas· 1 shared A. Casabianca· 1 shared A. Hedger· 1 shared A. Jahangir· 1 shared A. L. Massa· 1 shared A. Maiti· 1 shared A. P. Makohon-Moore· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperImmunology

A. Beck

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Author profile →

4 papers

Recent·Most cited

Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

A. Maiti, A. Hedger, W. Myint, V. Balachandran, J. Watts, C. A. Schiffer, H. Matsuo

The paper determines the structure of APOBEC3G bound to a DNA inhibitor, revealing the transition state geometry and providing insights for inhibitor design.

bioRxiv · Aug 15, 2022Biochemistry

Tumor-targeted delivery of childhood vaccine recall antigens by attenuated Listeria reduces pancreatic cancer

B. C. Selvanesan, D. Chandra, W. Quispe-Tintaya, A. Jahangir, A. Patel, K. Meena, R. Alberto Alves Da Silva, M. Friedman, J. Li, S. Siddiqui, S. K. Libutti, Z. Yuan, A. Beck, L. Tesfa, W. Koba, , C. Gravekamp

This study shows that delivering a childhood vaccine antigen via attenuated Listeria improves immunotherapy for pancreatic cancer by converting cold tumors into hot tumors and enhancing T cell activity.

bioRxiv · Jun 4, 2021 · PreprintImmunology

Pancreatic cancer prognosis is predicted by a novel ATAC-array technology for assessing chromatin accessibility

S. Dhara, S. Chhangawala, H. Chintalapudi, G. Askan, V. Aveson, A. L. Massa, L. Zhang, A. P. Makohon-Moore, N. Lecomte, J. P. Melchor, J. Bermeo, A. Cardenas, S. Sinha, D. Glassman, R. Nicolle, , S. D. Leach

The paper develops ATAC-Array, a low-cost chromatin accessibility assay, and shows it predicts pancreatic cancer prognosis based on chromatin accessibility patterns.

bioRxiv · Jan 21, 2021Cancer Biology

A Novel Model of Pancreatic Cancer Dormancy Reveals Mechanistic Insights and a Dormancy Gene Signature with Human Relevance

C. Dudgeon, C. R. Harris, Y. Chen, B. Ghaddar, A. Sharma, M. M. Shah, A. Roberts, A. Casabianca, E. Collisson, V. Balachandran, P. Vertino, S. De, D. R. Carpizo

This study introduces a novel pancreatic cancer dormancy model, identifies a dormancy gene signature, and reveals mechanisms including chromatin remodeling and CCL5 as a novel marker.

bioRxiv · Apr 13, 2020 · PreprintCancer Biology