Inhibition of tumor growth by a novel engineered chimeric toxin that cleaves activated mutant and wild-type RAS
V. Vidimar, G. L. Beilhartz, M. Park, M. Biancucci, M. B. Kieffer, D. R. Gius, R. A. Melnyk, K. J. Satchell
This paper develops a chimeric toxin that cleaves both mutant and wild-type RAS, reducing tumor burden in mouse models.
bioRxiv · Dec 17, 2019Cancer Biology