Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia.
K. Duszyc, J. von Pein, D. Ramnath, D. Currin-Ross, S. Verma, F. Lim, M. J. Sweet, K. Schroder, A. S. Yap
The paper shows that apical extrusion prevents apoptosis from triggering inflammation in epithelia by eliminating apoptotic cells before they activate an IL-8-driven inflammatory response.
bioRxiv · Feb 12, 2023Cell Biology