Macrophage-targeted DNA methyltransferase inhibitor SGI-1027 decreases atherosclerosis in ApoE-null mice
A. C. Marquez-Sanchez, A. Manzanares-Guzman, R. Carriles-Jaimes, L. Sanchez-Segura, D. Colin-Castelan, D. Kamen, E. K. Koltsova, A. Maritnez-Antonio, D. Rodriguez-Rios, G. d. C. Romo-Morales, G. Lund, S. Zaina
This study shows that macrophage-targeted DNA methyltransferase inhibitor SGI-1027 reduces atherosclerosis in ApoE-null mice by altering macrophage cytokine profiles and reducing atherosclerotic burden.
bioRxiv · Aug 22, 2023 · PreprintPathology