Mucosal vaccine adjuvant cyclic di-GMP differentiates lung moDCs into Bcl6+ and Bcl6- mature moDCs to induce lung memory CD4+ TH cells and lung TFH cells respectively
S. Mansouri, D. S. Katikaneni, H. Gogoi, l. jin
The paper shows cyclic di-GMP differentiates lung moDCs into Bcl6+ and Bcl6- subsets, which induce memory TH and TFH cells respectively, enhancing mucosal vaccine responses.
bioRxiv · Jun 4, 2020Immunology