Nucleolin acute degradation reveals novel functions in cell cycle progression and division in TNBC
J. Mills, A. Tessari, V. Anastas, D. S. Kumar, N. S. Rad, S. Lamba, I. Cosentini, A. Reers, Z. Zhu, W. Miles, V. COPPOLA, E. Cocucci, T. J. Magliery, H. Shive, A. E. Davies, , D. Palmieri
This study uses the AID system with CRISPR/Cas9 to acutely degrade nucleolin in TNBC cells, revealing its role in cell cycle progression and division, and showing that its abrogation enhances the efficacy of mitotic inhibitors.
bioRxiv · Jun 17, 2024 · PreprintCancer Biology