Z. Zhu

Nicotine Ameliorates α-synuclein Pre-formed Fibril-Induced Behavioral Deficits and Pathological Features in Mice

This study shows nicotine reduces α-synuclein pathology and behavioral deficits in mice induced by human α-synuclein pre-formed fibrils.

Construction of Animal Models Based on Exploring Pathological Features and Mechanisms of Different Locations in the Progression of DVT-APTE-CTEPD/CTEPH

This study constructs animal models to simulate different stages of DVT-APTE-CTEPD/CTEPH progression and compares their effectiveness in capturing pathological features.

Neuroprotective Effects of Bioactive Molecules Derived from Tobacco as Potential Therapeutic Candidates for Alzheimer Disease

The paper identifies three tobacco-derived compounds with neuroprotective effects against Alzheimer's disease using a genetic engineering approach with neural progenitor cells.

Engineered Migrasomes: Harnessing Core Migrasome Machinery and Hypotonic Shock to Develop a Robust and Thermally Stable Vaccine Platform

This study engineers migrasome-like vesicles (eMigrasomes) using hypotonic shock to create a stable, thermally robust vaccine platform that elicits strong immune responses.

Epigenetic reprogramming of autophagy leads to uncovering a novel therapeutic target for mutant IDH1 astrocytomas

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

A dual-gene reporter-amplifier architecture for enhancing the sensitivity of molecular MRI by water exchange

This paper develops a dual-gene reporter-amplifier system to enhance MRI sensitivity by using Aqp1 to facilitate water exchange, enabling detection of low-abundance Oatp1b3-expressing cells.

Chitinase 3-like-1 (CHI3L1) Inhibits Innate Anti-Tumor and Tissue Remodeling ImmuneResponses by Regulating CD47-SIRPα and CD24-Siglec10-Mediated Phagocytosis

This study shows CHI3L1 inhibits macrophage phagocytosis by modulating CD47-SIRPα and CD24-Siglec10 pathways, contributing to immune evasion in cancer and COPD.

Tracing the evolutionary emergence of the temperature sensing prion-like domain in EARLY FLOWERING 3 across the plant kingdom

The paper traces the evolutionary emergence of the prion-like domain in ELF3 across the plant kingdom, finding polyQ repeat length variation in Arabidopsis thaliana but weak association with environmental adaptation.

Transport and inhibition mechanism for VMAT2-mediated synaptic loading of monoamines

This study presents cryo-EM structures of VMAT2 bound to substrates and inhibitors, revealing conformational changes and mechanisms of ligand recognition and inhibition.

Complex epistatic interactions between ELF3, PRR9, and PRR7 regulates the circadian clock and plant physiology

The paper investigates the genetic interactions between ELF3, PRR9, and PRR7 in Arabidopsis, revealing complex epistatic relationships affecting circadian rhythms and plant development.

Manipulation of Bacterial ROS Production Leads to Self-escalating DNA Damage and Resistance-resistant Lethality for Intracellular Mycobacteria

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

Vacuolar H+-ATPase Determines Daughter Cell Fates through Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase Complex

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas

This study shows that H3.3-G34R mutations reprogram the tumor immune microenvironment in diffuse hemispheric gliomas, enhancing the efficacy of immune stimulatory gene therapy and leading to long-term survival in treated mice.

Rme-6 integrates EGFR trafficking and signalling to regulate ERK1/2 signalosome dynamics

This study shows Rme-6 coordinates EGFR trafficking and signaling to regulate ERK1/2 signalosome dynamics through CK2-mediated phosphorylation and endocytic trafficking.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis

The paper identifies chromatin classes in RA synovial tissue and links them to transcriptional cell states and genetic variants.

Toxoplasma gondii infection alters the recognition response of dendritic cells to stiffness substrate: A new model of cell durotaxis migration

This paper shows that Toxoplasma gondii infection changes dendritic cell durotaxis by altering F-actin structure and FAK phosphorylation, promoting parasite brain dissemination.

A unifying principle for global greenness patterns and trends

The paper presents a simple model that explains global greenness patterns and trends using two parameters, matching the accuracy of complex vegetation models.

Brainstem Dbh+ Neurons Control Chronic Allergen-Induced Airway Hyperreactivity

This study identifies Dbh+ neurons in the brainstem as critical for chronic allergen-induced airway hyperreactivity through molecular, anatomical, and functional analyses.

In vivo Modulation of Intraocular and Intracranial Pressures Causes Nonlinear and Non-monotonic Deformations of the Lamina Cribrosa and Scleral Canal

This study examines how changes in intraocular and intracranial pressures affect monkey optic nerve head morphology, finding nonlinear and non-monotonic deformations not explained by translaminar pressure difference.

T492I mutation alters SARS-CoV-2 properties via modulating viral non-structural proteins

The paper investigates the T492I mutation in SARS-CoV-2 NSP4, showing it increases transmissibility, replication, and antibody evasion by enhancing NSP5 cleavage efficiency and reducing viral RNA-associated chemokines.

Highly Sensitive and Specific Amyloid-β Oligomers Detection Using CRISPR-Cas12a Probe System aided by Graphene Oxide for Early Diagnosis of Alzheimer's Diseases

This study develops a CRISPR-Cas12a-based sensor enhanced with graphene oxide for specific and sensitive detection of amyloid-β oligomers, aiming to enable early Alzheimer's disease diagnosis.

Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes

The paper investigates γ-tubulin complex recruitment mechanisms at mitotic centrosomes in Drosophila, showing that Spd-2 and Cnn use different pathways to nucleate microtubules, with implications for centrosome robustness and microtubule dynamics.

Guild-level microbiome signature associated with COVID-19 severity and prognosis

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

An R-R-type MYB transcription factor promotes nonclimacteric pepper fruit ripening pigmentation

This study identifies a MYB transcription factor that regulates capsanthin biosynthesis in nonclimacteric pepper fruit, showing its role in carotenoid accumulation and interaction with abscisic acid.

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial LONP1

This study identifies FBXO11 loss as a driver of AML by promoting a stem cell program through mitochondrial dysregulation.

An exotic allele of barley EARLY FLOWERING 3 contributes to developmental plasticity at elevated temperatures

This study shows an exotic barley ELF3 allele improves yield stability at high temperatures by altering growth and developmental responses.

Propagation dynamics of electrotactic motility in large epithelial cell sheets

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

IKKα promotes lung adenocarcinoma growth through activation of ERK signaling via DARPP-32-mediated inhibition of PP1 activity

Metformin Alleviates Arthrofibrosis in Rat via Fibroblast Metabolic Reprogramming

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.