Author

V. Coppola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Orlacchio· 3 shared M. Chen· 3 shared A. Kenney· 2 shared A. La Ferlita· 2 shared C. Tsatsanis· 2 shared E. Chavdoula· 2 shared F. Amari· 2 shared G. I. Laliotis· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

A. Orlacchio

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Functional differences drive the selection of NRAS mutants in melanoma

B. M. Murphy, T. J. Weiss, A. M. Holderbaum, A. Dhakal, M. Fort, M. S. Bodnar, M. Chen, C. J. Burd, V. COPPOLA, C. E. Burd

This study shows that specific NRAS mutants drive melanoma formation in mice, with Q61R and Q61K being the most effective, while others like G12D or Q61Q are not.

bioRxiv · Jan 15, 2021 · PreprintCancer Biology

IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2.

G. I. Laliotis, A. Kenney, E. Chavdoula, A. Orlacchio, A. K. Kaba, A. La Ferlita, V. Anastas, C. Tsatsanis, J. D. Beane, L. Sehgal, V. Coppola, J. S. Yount, P. N. Tsichlis

The paper was withdrawn due to concerns about the validity of the reported alternative splicing mechanism of U2AF2 and potential data manipulation.

bioRxiv · Dec 26, 2020Cancer Biology

IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing.

G. I. Laliotis, E. Chavdoula, M. D. Paraskevopoulou, A. D. Kaba, A. La Ferlita, S. Singh, V. Anastas, S. Alaimo, A. Orlacchio, K. A. Nair, V. Taraslia, I. Vlachos, M. Capece, A. Hatzigeorgiou, D. I. Palmieri, , P. N. Tsichlis

The paper was withdrawn due to concerns about the validity of the reported splicing mechanism and data integrity.

bioRxiv · Jul 14, 2020Cancer Biology

Tagging allows faithful tracing of expression and enhances biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin.

S. Soliman, A. E. Stark, M. Gardner, S. W. Harshman, C. C. Breece, F. Amari, A. Orlacchio, M. Chen, A. Tessari, J. A. Martin, R. Visone, M. A. Freitas, K. La Perle, D. Palmieri, V. COPPOLA

The paper generates a novel mouse strain with a tagged RanBP9 protein, enabling reliable detection and revealing its interaction with Nucleolin.

bioRxiv · Dec 3, 2019Bioengineering

IFITM3 protects the heart during influenza virus infection

A. Kenney, T. M. McMichael, A. Imas, N. M. Chesarino, L. Zhang, L. E. Dorn, Q. Wu, O. Alfaour, F. Amari, M. Chen, A. Zani, M. Chemudupati, F. Accornero, V. Coppola, M. V. S. Rajaram, J. S. Yount

This study shows that IFITM3 deficiency in mice worsens influenza virus-induced cardiac dysfunction, revealing its protective role in the heart during infection.

bioRxiv · Jan 11, 2019Immunology