Discovery of thyrocyte heterogeneity reveals an essential role of Notch signaling in thyroid function and mammalian homeostasis
L. Mosteiro, T. T. T. Nguyen, S. Hankeova, M. Reichelt, S. M. Vandriel, Z. Lai, F. K. Choudhury, D. Sangaraju, B. M. Kamath, A. Scherl, R. Piskol, C. W. Siebel
The paper identifies thyrocyte subtypes in adult mouse thyroid and shows Notch signaling regulates mitochondrial function and thyroid hormone levels, linking it to hypothyroidism in Alagille Syndrome.
bioRxiv · Sep 2, 2022 · PreprintCell Biology