M. Reichelt

Influence of plant defense signaling and innate insect metabolic differences to the overall performance of fall armyworm (Spodoptera frugiperda) corn and rice strains on maize as a host

Beyond defense: Glucosinolate structural diversity shapes recruitment of a metabolic network of leaf-associated bacteria

The paper shows that structural variations in glucosinolates affect bacterial community recruitment in Arabidopsis thaliana, with allyl-GLS enriching Burkholderiales bacteria.

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.

Plant geographic distribution influences chemical defenses in native and introduced Plantago lanceolata populations

This study shows that introduced Plantago lanceolata populations have higher chemical defenses than native populations without reducing biomass.

Discovery of thyrocyte heterogeneity reveals an essential role of Notch signaling in thyroid function and mammalian homeostasis

The paper identifies thyrocyte subtypes in adult mouse thyroid and shows Notch signaling regulates mitochondrial function and thyroid hormone levels, linking it to hypothyroidism in Alagille Syndrome.

Leaf bacterial community structure and variation in wild ruderal plants are shaped by the interaction of host species and defense chemistry with environment

The paper examines how host species, defense chemistry, and environmental factors shape leaf bacterial community variation in wild ruderal plants.

A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

The paper shows that an insect beta-glucosidase metabolizes a dandelion defense compound, reducing its toxicity and altering herbivore feeding preference.

A specialist flea beetle manipulates and tolerates the activated chemical defense in its host plant

This study investigates how the flea beetle Phyllotreta armoraciae sequesters glucosinolates from its host plant and tolerates their hydrolysis, showing that plant myrosinases reduce sequestration but beetles avoid gut hydrolysis through absorption and inactivation of myrosinases.

Sugar transporters enable a leaf beetle to accumulate plant defense compounds

This study identifies sugar transporter genes in beetles that prevent the excretion of plant defense compounds, enabling their accumulation for defense.

Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury

This study shows ASIC1a contributes to cardiac ischemia-reperfusion injury and that inhibiting it protects heart function, with genetic variants linked to myocardial infarction.

Novel inhibitors of E. coli lipoprotein diacylglyceryl transferase are insensitive to resistance caused by lpp deletion

The paper identifies Lgt inhibitors that remain effective against E. coli even when lpp is deleted, showing Lgt is a robust antibacterial target.

Proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

This study shows that loss of Atg16l1 in macrophages enhances antimicrobial immunity against Shigella flexneri via the oxidative stress response.

A light-dependent molecular link between competition cues and defense responses in plants

This study identifies a sulfotransferase that links light signals to jasmonate signaling in plants, enabling prioritization of shade avoidance over defense.