Author

C. W. Siebel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Jovicic· 1 shared A. S. Peterson· 1 shared A. Scherl· 1 shared B. A. Hall· 1 shared B. M. Kamath· 1 shared D. Sangaraju· 1 shared E. Abby· 1 shared F. K. Choudhury· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

A. Jovicic

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Discovery of thyrocyte heterogeneity reveals an essential role of Notch signaling in thyroid function and mammalian homeostasis

L. Mosteiro, T. T. T. Nguyen, S. Hankeova, M. Reichelt, S. M. Vandriel, Z. Lai, F. K. Choudhury, D. Sangaraju, B. M. Kamath, A. Scherl, R. Piskol, C. W. Siebel

The paper identifies thyrocyte subtypes in adult mouse thyroid and shows Notch signaling regulates mitochondrial function and thyroid hormone levels, linking it to hypothyroidism in Alagille Syndrome.

bioRxiv · Sep 2, 2022 · PreprintCell Biology

Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth

E. Abby, S. C. Dentro, M. W. J. Hall, J. C. Fowler, S. H. Ong, R. Sood, C. W. Siebel, M. Gerstung, B. A. Hall, P. Jones

The paper shows NOTCH1 mutations promote clonal expansion in normal esophageal epithelium but hinder tumor growth, suggesting NOTCH1 inhibition could prevent esophageal squamous cancer.

bioRxiv · Jun 18, 2021 · PreprintCancer Biology

Heterogeneity of satellite cells implicates DELTA1/ NOTCH2 signaling in self-renewal

V. Yartseva, L. D. Goldstein, J. Rodman, L. Kates, M. Z. Chen, Y.-J. J. Chen, O. Foreman, C. W. Siebel, Z. Modrusan, A. S. Peterson, A. Jovicic

The paper identifies DELTA1/NOTCH2 signaling as critical for satellite cell self-renewal during muscle regeneration by analyzing single-cell RNA sequencing data and using antagonistic antibodies.

bioRxiv · Oct 30, 2019Cell Biology