BiophysicsbioRxiv
The structure of pathogenic huntingtin exon-1 defines the bases of its aggregation propensity
C. A. Elena-Real, A. Sagar, A. Urbanek…·P. Bernado
This study investigates how the structure of pathogenic huntingtin exon-1 with expanded poly-Q tracts influences its aggregation propensity and fibril formation.
DOI 10.1038/s41594-023-00920-0