A. Barducci

Nucleation of Biomolecular Condensates from Finite-Sized Simulations

This paper presents a method to estimate thermodynamic and kinetic parameters of protein condensates from finite-sized simulations, showing differences in nucleation behavior between NDDX4 and FUS-LC.

The structure of pathogenic huntingtin exon-1 defines the bases of its aggregation propensity

This study investigates how the structure of pathogenic huntingtin exon-1 with expanded poly-Q tracts influences its aggregation propensity and fibril formation.

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair

This study shows SLX4 forms membraneless compartments that regulate SUMO-RNF4 pathway activity and DNA repair processes.

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

The paper presents a cryo-EM structure of the AHR complex bound to a ligand, revealing structural details of its activation mechanism and ligand-binding specificity.

Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR

The paper uses MAS NMR and computational methods to show a flexible loop in TET2 aminopeptidase is critical for catalytic function and substrate processing.

Arginine multivalency stabilizes protein/RNA condensates

This study uses molecular dynamics simulations to show that arginine stabilizes protein/RNA condensates more effectively than lysine due to its multivalency.

Unraveling molecular interactions in a phase-separating protein by atomistic simulations

This study uses atomistic simulations to investigate molecular interactions driving phase separation in the N-terminal disordered region of DEAD-box helicase 4.

DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes

The paper introduces a DNA-segment-capture model for SMC protein loop extrusion, predicting tension-dependent translocation velocity and step size.

Interplay of protein disorder in retinoic acid receptor heterodimer and its corepressor regulates gene expression

This study shows that the structural dynamics of the H12 helix in RXR/RAR heterodimers and the intrinsic disorder of N-CoR regulate gene expression through conformational changes and corepressor complex formation.

A catch-bond drives stator mechanosensitivity in the Bacterial Flagellar Motor

The paper measures stator unit dynamics in bacterial flagellar motors under varying loads, finding that dissociation rates decrease with load, suggesting a catch-bond mechanism for mechano-sensitivity.

Molecular chaperones inject energy from ATP hydrolysis into the non-equilibrium stabilisation of native proteins

The paper demonstrates that molecular chaperones use ATP hydrolysis energy to stabilize proteins in their active state under non-equilibrium conditions.