Author

A. Estana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Sagar· 2 shared J. Cortes· 2 shared P. Bernado· 2 shared A. Barducci· 1 shared A. Barozet· 1 shared A. Fournet· 1 shared A. Morato· 1 shared A. S. Holehouse· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiophysics

A. Sagar

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2 papers

Recent·Most cited

The structure of pathogenic huntingtin exon-1 defines the bases of its aggregation propensity

C. A. Elena-Real, A. Sagar, A. Urbanek, M. Popovic, A. Morato, A. Estana, A. Fournet, X. L. Lund, Z.-D. Shi, L. Costa, A. Thureau, F. Allemand, R. E. Swenson, P.-E. Milhiet, A. Barducci, , P. Bernado

This study investigates how the structure of pathogenic huntingtin exon-1 with expanded poly-Q tracts influences its aggregation propensity and fibril formation.

bioRxiv · Oct 25, 2022Biophysics

Conformational buffering underlies functional selection in intrinsically disordered protein regions

N. S. Gonzalez-Foutel, W. M. Borcherds, J. Glavina, S. Barrera-Vilarmau, A. Sagar, A. Estana, A. Barozet, G. Fernandez-Ballester, C. Blanes-Mira, I. E. Sanchez, G. de Prat Gay, J. Cortes, P. Bernado, R. V. Pappu, A. S. Holehouse, , L. B. Chemes

The paper identifies conformational buffering as a mechanism that conserves spatial dimensions in disordered protein regions despite sequence variation, enabling functional selection.

bioRxiv · May 14, 2021Biophysics