A. Sagar

VISUALIZING THE NUCLEATING AND CAPPED STATES OF F-ACTIN BY Ca2+-GELSOLIN: SAXS DATA BASED STRUCTURES OF BINARY AND TERNARY COMPLEXES

This study uses SAXS to reveal structural insights into how Ca2+-gelsolin depolymerizes and caps F-actin, identifying GA and GA2 complexes as key intermediates.

Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction

The paper investigates how phosphorylation of GPCR C-terminal domains affects their conformation and arrestin interaction, revealing phosphorylation-dependent structural changes that influence signaling outcomes.

The structure of pathogenic huntingtin exon-1 defines the bases of its aggregation propensity

This study investigates how the structure of pathogenic huntingtin exon-1 with expanded poly-Q tracts influences its aggregation propensity and fibril formation.

Tip-links serve as force-pass filter to fulfil the role of gating-springs

The paper investigates the mechanical behavior of tip-links in hearing, showing they act as low-force pass filters through slip-ideal-slip bond dynamics and their role in gating-springs.

Transient interactions drive the lateral clustering of Cadherin-23 on membrane

This study shows that transient hydrophobic interactions drive lateral clustering of cadherin-23 on membranes, enhancing cell adhesion without requiring specific cis-dimer interactions.

Conformational buffering underlies functional selection in intrinsically disordered protein regions

The paper identifies conformational buffering as a mechanism that conserves spatial dimensions in disordered protein regions despite sequence variation, enabling functional selection.

Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation

This study investigates the structure and function of SslE in E. coli biofilm maturation, showing its role in aggregate formation and exopolysaccharide distribution under acidic conditions.

Convolutional Neural Networks for Classifying Melanoma Images

This paper develops a convolutional neural network for melanoma classification using the ISIC dataset, achieving high accuracy and outperforming previous methods.

On Using Transfer Learning For Plant Disease Detection

The paper applies transfer learning using ResNet50 to classify plant diseases from images, achieving high accuracy and other metrics on a multi-class dataset.

Broken force dispersal network in tip-links by the mutations induces hearing-loss

The paper investigates how mutations in tip-link proteins disrupt force transmission in inner ear sensors, leading to hearing loss, and shows that Ca2+ can restore function in mutants.

Molecular mechanism of cell-cell adhesion mediated by cadherin-23

This study identifies a novel antiparallel-binding interface of cadherin-23 homodimer and shows how mutations in this interface affect cell-cell adhesion and cancer.