K. A. White

Intracellular pH regulates beta-catenin with low pH increasing adhesion and signaling functions

This paper shows that intracellular pH regulates beta-catenin stability and function, with low pH increasing its abundance and activity while high pH decreases it.

A 128-ch area-efficient neurochemical-sensing front-end for FSCV recordings of dopamine

The paper introduces a 128-channel neurochemical-sensing microchip for high-resolution dopamine recordings using FSCV.

Intracellular pH differentially regulates transcription of metabolic and signaling pathways in normal epithelial cells

The paper shows that intracellular pH changes regulate transcription of signaling and metabolic pathways in normal epithelial cells, with high pH increasing Notch1 and glycolytic gene expression.

A 512-ch dual-mode microchip for simultaneous measurements of electrophysiological and neurochemical activities

The paper introduces a dual-mode CMOS microchip that simultaneously measures electrophysiological and neurochemical activities with high spatiotemporal resolution.

Single-cell intracellular pH dynamics regulate the cell cycle by timing G1 exit and the G2 transition

This study shows that intracellular pH dynamics regulate cell cycle transitions by timing G1 exit and G2/M transition in human cells.

An optogenetic tool to raise intracellular pH in single cells and drive localized membrane dynamics

This paper introduces an optogenetic tool using ArchT to manipulate intracellular pH in single cells and demonstrates its ability to drive membrane dynamics.

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity

This paper identifies an acidic residue in IDH1 that regulates catalysis and pH sensitivity through conformational changes.

A Wirelessly Powered Implantable CMOS Neural Recording Sensor Array using Pulse-based Neural Amplifier

This paper presents an implantable neural recording device that wirelessly powers and transmits data, enabling in vivo brain measurements without transcranial wiring.

Parallel 1024-ch Cyclic Voltammetry on Monolithic CMOS Electrochemical Detector Array

This paper develops a 1024-channel CMOS electrochemical detector array capable of parallel cyclic voltammetry to assess electrode quality and surface contamination.

A multimodal approach to identify clinically relevant parameters to monitor disease progression in a preclinical model of neuropediatric disease

The paper uses a multimodal approach to identify clinically relevant parameters for tracking disease progression in a mouse model of Batten disease.