Cross-reactive single-domain antibodies to hemagglutinin stem region protect mice from group 1 influenza A virus infection
D. V. Voronina, A. S. Bandelyuk, A. S. Dzharullaeva, O. Popova, V. Y. Kan, I. B. Esmagambetov, I. A. Favorskaya, D. V. Shcheblyakov, B. S. Naroditskiy, A. L. Gintsburg
This study modifies two single-domain antibodies to enhance their neutralizing activity against multiple influenza A virus subtypes and demonstrates their protective efficacy in mice.
bioRxiv · Sep 29, 2022 · PreprintImmunology