C subunit of the ATP synthase is an amyloidogenic channel-forming peptide: possible implications in mitochondrial pathogenesis
G. F. Amodeo, B. Y. Lee, N. Krilyuk, C. T. Filice, D. Valyuk, D. Otzen, S. Noskov, Z. Leonenko, E. V. Pavlov
This study identifies the c subunit of ATP synthase as an amyloidogenic peptide that forms ion channels and may contribute to mitochondrial toxicity through mechanisms similar to neurodegenerative proteins.
bioRxiv · Jan 16, 2020 · PreprintBiophysics