Author

E. V. Pavlov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

B. Y. Lee· 1 shared C. T. Filice· 1 shared D. Otzen· 1 shared D. Valyuk· 1 shared G. F. Amodeo· 1 shared J. F. Conway· 1 shared J. N. Bazil· 1 shared J. O. Strubbe· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

B. Y. Lee

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3 papers

Recent·Most cited

Both ANT and ATPase are essential for mitochondrial permeability transition but not depolarization

M. A. Neginskaya, S. E. Morris, E. V. Pavlov

The paper investigates the roles of ATP synthase and ANT in mitochondrial permeability transition, finding they are essential for high-conductance PTP but not depolarization.

bioRxiv · Nov 16, 2021Cell Biology

The Mitochondrial Permeability Transition Phenomenon Elucidated by Cryo-EM Reveals the Genuine Impact of Calcium Overload on Mitochondrial Structure and Function

J. O. Strubbe, J. R. Schrad, E. V. Pavlov, J. F. Conway, K. N. Parent, J. N. Bazil

The study uses cryo-EM to show how calcium overload causes mitochondrial permeability transition by forming calcium phosphate granules and inner membrane fragmentation, and reveals cyclosporin A's role in preserving inner membrane structure.

Scientific Reports · Jan 13, 2021Peer-reviewedCell Biology

C subunit of the ATP synthase is an amyloidogenic channel-forming peptide: possible implications in mitochondrial pathogenesis

G. F. Amodeo, B. Y. Lee, N. Krilyuk, C. T. Filice, D. Valyuk, D. Otzen, S. Noskov, Z. Leonenko, E. V. Pavlov

This study identifies the c subunit of ATP synthase as an amyloidogenic peptide that forms ion channels and may contribute to mitochondrial toxicity through mechanisms similar to neurodegenerative proteins.

bioRxiv · Jan 16, 2020 · PreprintBiophysics