Author

D. W. Spelman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

A. W. J. Jenney· 3 shared C. L. Gorrie· 2 shared K. E. Holt· 2 shared M. Mirceta· 2 shared R. A. Strugnell· 2 shared R. R. Wick· 2 shared A. Dennison· 1 shared A. Y. Peleg· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

A. W. J. Jenney

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Genomic dissection of endemic carbapenem resistance: metallo-beta-lactamase gene dissemination through clonal, plasmid and integron transfer pathways

N. Macesic, J. Hawkey, B. Vezina, J. A. Wisniewski, H. Cottingham, L. V. Blakeway, T. Harshegyi, K. Pragastis, G. Z. Badoordeen, A. Dennison, D. W. Spelman, A. W. J. Jenney, A. Y. Peleg

The paper tracks the evolution and spread of the blaIMP-4 gene across multiple bacterial strains and plasmids in a hospital setting over two decades.

bioRxiv · Mar 25, 2023 · PreprintMicrobiology

Antimicrobial resistant Klebsiella pneumoniae carriage and infection in specialized geriatric care wards linked to acquisition in the referring hospital

C. L. Gorrie, M. Mirceta, R. R. Wick, L. M. Judd, K. L. Wyres, N. R. Thomson, R. A. Strugnell, N. F. Pratt, J. F. Garlick, K. M. Watson, P. C. Hunter, S. A. McGloughlin, D. W. Spelman, A. W. J. Jenney, K. E. Holt

The paper investigates K. pneumoniae carriage and infection in geriatric wards, finding that most isolates originated from patients' gut microbiomes, while ESBL strains were acquired in the referring hospital.

bioRxiv · Nov 13, 2017Microbiology

Gastrointestinal carriage is a major reservoir of K. pneumoniae infection in intensive care patients

C. L. Gorrie, M. Mirceta, R. R. Wick, D. J. Edwards, R. A. Strugnell, N. Pratt, J. Garlick, K. Watson, D. Pilcher, S. McGloughlin, D. W. Spelman, A. W. J. Jenney, K. E. Holt

This study finds that gastrointestinal carriage of K. pneumoniae is a significant risk factor for infection in ICU patients, with half of infections originating from the patient's own microbiota.

bioRxiv · Dec 23, 2016Microbiology