Author

R. R. Wick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:whole-genome sequencing· 6 Research Focus:host-pathogen & immune response· 4 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:Bayesian inference· 1

Frequent Co-Authors

K. E. Holt· 8 shared K. L. Wyres· 6 shared L. M. Judd· 6 shared C. L. Gorrie· 3 shared A. Jenney· 2 shared A. Tokolyi· 2 shared A. W. J. Jenney· 2 shared D. W. Spelman· 2 shared

Activity by Year

2016-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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8 shared papersMicrobiology

K. E. Holt

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Quantifying plasmid movement in drug-resistant Shigella species using phylodynamic inference

N. F. Müller, R. R. Wick, L. M. Judd, D. A. Williamson, T. Bedford, B. Howden, S. Duchene, D. J. Ingle

This paper introduces a method to quantify plasmid movement in Shigella species over time, finding higher transfer rates for small plasmids and recent dissemination of a multidrug-resistant plasmid.

bioRxiv · Oct 27, 2022Evolutionary Biology

Linear plasmids in Klebsiella and other Enterobacteriaceae

J. Hawkey, H. Cottingham, A. Tokolyi, R. R. Wick, L. M. Judd, L. Cerdeira, D. de Oliveira Garcia, K. L. Wyres, K. E. Holt

This study identifies and characterizes linear plasmids in Klebsiella pneumoniae and other Enterobacteriaceae, revealing their phylogenetic diversity and potential for horizontal transfer.

bioRxiv · Dec 14, 2021Microbiology

Genome-resolved metagenomics and detailed geochemical speciation analyses yield new insights into microbial mercury cycling in geothermal springs

C. Gionfriddo, M. Stott, J. F. Power, J. M. Ogorek, D. P. Krabbenhoft, R. R. Wick, K. E. Holt, L.-X. Chen, B. C. Thomas, J. F. Banfield, J. W. Moreau

This paper identifies microorganisms involved in mercury cycling in geothermal springs using metagenomics and geochemical analysis, revealing new insights into microbial mercury speciation and biogeochemical processes.

bioRxiv · Feb 3, 2020Microbiology

Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae

K. L. Wyres, R. R. Wick, L. M. Judd, R. Froumine, A. Tokolyi, C. L. Gorrie, M. M. C. Lam, S. Duchene, A. Jenney, K. E. Holt

The paper compares the evolutionary dynamics of horizontal gene transfer in drug-resistant and virulent Klebsiella pneumoniae clones to assess the risk of gene convergence.

bioRxiv · Sep 12, 2018Microbiology

Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

K. L. Wyres, J. Hawkey, M. A. K. Hetland, A. Fostervold, R. R. Wick, L. M. Judd, M. Hamidian, B. P. Howden, I. H. Lohr, K. E. Holt

The paper tracks the emergence and global spread of a CTX-M-15-producing K. pneumoniae strain ST307, showing it originated in the mid-1990s and is associated with a plasmid containing antimicrobial resistance genes.

bioRxiv · Jun 21, 2018Microbiology

Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations

M. M. C. Lam, R. R. Wick, K. L. Wyres, C. Gorrie, L. M. Judd, A. Jenney, S. Brisse, K. E. Holt

The paper analyzes the prevalence and evolution of yersiniabactin-encoding mobile elements in Klebsiella pneumoniae using whole genome sequences, identifying diverse lineages and novel dispersal mechanisms.

bioRxiv · Mar 12, 2018Microbiology

Kaptive Web: user-friendly capsule and lipopolysaccharide serotype prediction for Klebsiella genomes

R. R. Wick, E. Heinz, K. E. Holt, K. L. Wyres

Kaptive Web is an online tool for typing Klebsiella K and O loci in genome assemblies, showing extensive diversity in these loci among clinical isolates.

bioRxiv · Feb 5, 2018Microbiology

Antimicrobial resistant Klebsiella pneumoniae carriage and infection in specialized geriatric care wards linked to acquisition in the referring hospital

C. L. Gorrie, M. Mirceta, R. R. Wick, L. M. Judd, K. L. Wyres, N. R. Thomson, R. A. Strugnell, N. F. Pratt, J. F. Garlick, K. M. Watson, P. C. Hunter, S. A. McGloughlin, D. W. Spelman, A. W. J. Jenney, K. E. Holt

The paper investigates K. pneumoniae carriage and infection in geriatric wards, finding that most isolates originated from patients' gut microbiomes, while ESBL strains were acquired in the referring hospital.

bioRxiv · Nov 13, 2017Microbiology

Gastrointestinal carriage is a major reservoir of K. pneumoniae infection in intensive care patients

C. L. Gorrie, M. Mirceta, R. R. Wick, D. J. Edwards, R. A. Strugnell, N. Pratt, J. Garlick, K. Watson, D. Pilcher, S. McGloughlin, D. W. Spelman, A. W. J. Jenney, K. E. Holt

This study finds that gastrointestinal carriage of K. pneumoniae is a significant risk factor for infection in ICU patients, with half of infections originating from the patient's own microbiota.

bioRxiv · Dec 23, 2016Microbiology