D. Warshaw

Myosin-Binding Protein C Stabilizes, But Is Not the Sole Determinant of SRX Myosin in Cardiac Muscle

This study investigates the role of MyBP-C in stabilizing the SRX myosin state in cardiac muscle using transgenic mice and super-resolution microscopy, finding that MyBP-C's N-terminal region is critical for maintaining SRX along the thick filament.

Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time

The paper uses super-resolution microscopy to image single ATP molecule consumption in relaxed rat soleus muscle sarcomeres, revealing two distinct hydrolysis rates with the slower rate localized to the C-zone where MyBP-C is present.