S. R. Nelson

Myosin-Binding Protein C Stabilizes, But Is Not the Sole Determinant of SRX Myosin in Cardiac Muscle

This study investigates the role of MyBP-C in stabilizing the SRX myosin state in cardiac muscle using transgenic mice and super-resolution microscopy, finding that MyBP-C's N-terminal region is critical for maintaining SRX along the thick filament.

A circular zone of attachment to the extracellular matrix provides directionality to the motility of Toxoplasma gondii in 3D

This study uses 3D traction force mapping to show that Toxoplasma gondii generates inward-directed forces at a circular zone of attachment to the extracellular matrix, providing directionality to its motility.

Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time

The paper uses super-resolution microscopy to image single ATP molecule consumption in relaxed rat soleus muscle sarcomeres, revealing two distinct hydrolysis rates with the slower rate localized to the C-zone where MyBP-C is present.

MYOSIN VA TRANSPORT OF LIPOSOMES IN THREE-DIMENSIONAL ACTIN NETWORKS IS MODULATED BY ACTIN FILAMENT DENSITY, POSITION, AND POLARITY

This study investigates how actin filament density, position, and polarity affect MyoVa-mediated liposome transport in 3D actin networks using in vitro models and computational simulations.