Structural basis for Rab8a GTPase recruitment of RILPL2 via LRRK2 phosphorylation of switch 2
A. R. Khan, D. R. Alessi, D. Waschbusch, E. Purlyte, P. Pal, E. McGrath
The paper reports the crystal structure of phospho-Rab8a bound to RILPL2, revealing how LRRK2 phosphorylation enables specific interaction and regulation of ciliogenesis.
bioRxiv · Aug 19, 2019Biochemistry