Author

E. Purlyte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

D. R. Alessi· 4 shared C. Limouse· 2 shared C. Y. Chiang· 2 shared F. Tonelli· 2 shared H. S. Dhekne· 2 shared P. Lis· 2 shared P. Pal· 2 shared S. R. Pfeffer· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiochemistry

D. R. Alessi

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Author profile →

4 papers

Recent·Most cited

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase

H. S. Dhekne, F. Tonelli, W. M. Yeshaw, C. Y. Chiang, C. Limouse, E. Jaimon, E. Purlyte, D. R. Alessi, S. R. Pfeffer

The paper identifies Rab12 as a critical activator of pathogenic LRRK2 kinase through a CRISPR-based screen and structural analysis.

bioRxiv · Feb 17, 2023Biochemistry

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

E. G. Vides, A. Adhikari, C. Y. Chiang, P. Lis, E. Purlyte, C. Limouse, J. L. Shumate, E. S. Lasso, H. S. Dhekne, D. R. Alessi, S. R. Pfeffer

This study identifies two distinct binding sites on LRRK2 that mediate its membrane recruitment and activation through Rab GTPase interactions, revealing a feed-forward pathway for kinase activity regulation.

bioRxiv · Apr 25, 2022Biochemistry

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

A. U. Malik, A. Karapetsas, R. S. Nirujogi, S. Mathea, P. Pal, P. Lis, M. Taylor, E. Purlyte, R. Gourlay, M. Dorward, S. Weidlich, R. Toth, N. K. Polinski, S. Knapp, F. Tonelli, D. R. Alessi

This study identifies distinct Rab proteins phosphorylated by LRRK1 and LRRK2, showing they are regulated by different mechanisms and respond differently to inhibitors.

bioRxiv · Nov 25, 2020Biochemistry

Structural basis for Rab8a GTPase recruitment of RILPL2 via LRRK2 phosphorylation of switch 2

A. R. Khan, D. R. Alessi, D. Waschbusch, E. Purlyte, P. Pal, E. McGrath

The paper reports the crystal structure of phospho-Rab8a bound to RILPL2, revealing how LRRK2 phosphorylation enables specific interaction and regulation of ciliogenesis.

bioRxiv · Aug 19, 2019Biochemistry