Amyloid-β seeding effects are dependent on the presence of knock-in genes in the AppNL-G-F mice.
S. G. Lacoursiere, D. Westaway, J. Safar, M. H. Mohajerani, R. J. Sutherland
This study seeds Aβ peptides into AppNL-G-F mice to assess their impact on cognition and pathology, finding effects depend on the presence of the humanized App gene and Aβ in the seed.
bioRxiv · May 28, 2022 · PreprintAnimal Behavior & Cognition