Accumulation of Treg cells is detrimental in late-onset (aged) mouse model of multiple sclerosis
W. Wang, R. Thomas, J. Oh, D.-M. Su
This study shows that accumulated Treg cells in aged mice worsen experimental autoimmune encephalomyelitis (EAE) by disrupting Treg/Teff balance and impairing CNS immune cell trafficking.
bioRxiv · Dec 16, 2021 · PreprintImmunology