Vaccine imprinting drives increased SARS-CoV-2 variant infection in children
Timothy S. Johnston, Rahul Subramanian, Wakinyan Benhamou, Emily Howerton, Robin Schlesinger, Stephen D. Schmidt, Rachel Kazmierski, Mike Castro, Bob C. Lin, Amy R. Henry, Sarah C. Smith, Jesmine Roberts-Torres, Farida Laboune, I‐Ting Teng, Shuishu Wang, , Daniel C. Douek
The paper shows that vaccine imprinting influences susceptibility to SARS-CoV-2 variants in children by linking immune history, antibody neutralization, and infection risk.
bioRxiv · Aug 17, 2026 · PreprintImmunology