Molecular Visualization of Neuronal TDP43 Pathology In Situ
Amanda L. Erwin, Martin G. Fernandez, Matthew L. Chang, Durga Attili, Michael Bekier, Emile S. Pinarbasi, Jennifer E. Russ, Renaldo Sutanto, Dafydd Thomas, Xinfei Shen, Ryan D. Baldridge, Elizabeth M.H. Tank, Sami J. Barmada, Shyamal Mosalaganti
This study uses a multimodal cryo-correlative microscopy pipeline to visualize TDP43 mislocalization and aggregation in iPSC-derived neurons and patient tissue, revealing ordered fibrils in autophagosomes and lysosomes.
bioRxiv · Aug 19, 2024 · PreprintNeuroscience