Martin G. Fernandez

CTE-Type Tau Filaments in Alzheimer's Disease with Co-morbid LATE-NC

The paper determines the structure of tau filaments in Alzheimer's disease patients with co-morbid LATE-NC using cryo-electron microscopy, revealing a CTE-type tau fold in addition to the Alzheimer's fold.

Neurodegeneration risk variants promote lysosomal TMEM106B fibrilaccumulation

The paper identifies TMEM106B fibril accumulation as a shared mechanism in neurodegeneration linked to genetic variants in TMEM106B and GRN.

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties

This study shows that endogenous retrovirus-like proteins RTL8 and PEG10 regulate UBQLN2's recruitment to stress granules and alter their functional properties.

Molecular Visualization of Neuronal TDP43 Pathology In Situ

This study uses a multimodal cryo-correlative microscopy pipeline to visualize TDP43 mislocalization and aggregation in iPSC-derived neurons and patient tissue, revealing ordered fibrils in autophagosomes and lysosomes.