NeurosciencebioRxivPreprint
Molecular Visualization of Neuronal TDP43 Pathology In Situ
Amanda L. Erwin, Martin G. Fernandez, Matthew L. Chang…·Shyamal Mosalaganti
This study uses a multimodal cryo-correlative microscopy pipeline to visualize TDP43 mislocalization and aggregation in iPSC-derived neurons and patient tissue, revealing ordered fibrils in autophagosomes and lysosomes.
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