Structural basis of lipid-mediated gating in a two-pore domain potassium channel
Fumiya K. Sano, Go Kasuya, Kohei Yamaguchi, Takehiro Suzuki, Daichi Yamanouchi, Kanehisa HASHIMOTO, Masataka Inoue, Kazuhiro Sawada, Ryuichiro Ishitani, Kenjiro Yoshimura, Hisato Hirano, Yuzuru Itoh, Koichi Nakajo, Naoshi Dohmae, Yoshiaki Kise, Osamu Nureki
This study presents the cryo-EM structure of TOK1, revealing its unique domain architecture and lipid-mediated gating mechanism through structural and functional analyses.
bioRxiv · Nov 12, 2025 · PreprintMolecular Biology