Author

Yuzuru Itoh

The University of TokyoORCID 0000-0001-7802-5572Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 2 Organism:E. coli· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Assay:cryo-EM· 1

Frequent Co-Authors

Osamu NurekiiD· 4 shared Fumiya K. SanoiD· 3 shared Hideki TaguchiiD· 2 shared Y. AndoiD· 2 shared Yuhei ChadaniiD· 2 shared Akinao KoboiD· 1 shared Alexey AmuntsiD· 1 shared Anas KhawajaiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersBiochemistry

Osamu NurekiORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Mitochondrial translation termination, recycling, reinitiation, and rescue for in-frame and out-of-frame contexts

Taisei Wakigawa, Mari Mito, Qi Fang, Yuzuru Itoh, Yoichi Shinkai, Shintaro Iwasaki

The paper investigates mitochondrial translation termination, recycling, and quality control mechanisms using Ribo-Seq and Disome-Seq, revealing roles of release factors and rescue mechanisms.

Nature Communications · Jul 21, 2026Peer-reviewedMolecular Biology

Structural insights into YheS-mediated release of SecM-arrested ribosome.

Kaishi Iso, Toma Ikeda, Kohei Yamasaki, Y. Ando, Fumiya K. Sano, Tadaomi Furuta, Hideki Taguchi, Osamu Nureki, Yuhei Chadani, Yuzuru Itoh

The paper elucidates the mechanism by which YheS releases SecM-arrested ribosomes using cryo-EM and molecular dynamics simulations.

Nature Communications · Jun 9, 2026Peer-reviewedBiochemistry

Structural basis of lipid-mediated gating in a two-pore domain potassium channel

Fumiya K. Sano, Go Kasuya, Kohei Yamaguchi, Takehiro Suzuki, Daichi Yamanouchi, Kanehisa HASHIMOTO, Masataka Inoue, Kazuhiro Sawada, Ryuichiro Ishitani, Kenjiro Yoshimura, Hisato Hirano, Yuzuru Itoh, Koichi Nakajo, Naoshi Dohmae, Yoshiaki Kise, Osamu Nureki

This study presents the cryo-EM structure of TOK1, revealing its unique domain architecture and lipid-mediated gating mechanism through structural and functional analyses.

bioRxiv · Nov 12, 2025 · PreprintMolecular Biology

A newly-identified mini-hairpin shaped nascent peptide blocks translation termination by a novel mechanism.

Y. Ando, Akinao Kobo, Tatsuya Niwa, Ayako Yamakawa, Suzuna Konoma, Yuki Kobayashi, Osamu Nureki, Hideki Taguchi, Yuzuru Itoh, Yuhei Chadani

The paper identifies two novel ribosome arrest peptides in E. coli and elucidates their unique mechanism of translation arrest.

bioRxiv · May 31, 2024 · PreprintMolecular Biology

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

Shirsha Saha, Fumiya K. Sano, Saloni Sharma, Manisankar Ganguly, Sayantan Saha, Hiroaki Akasaka, Takaaki Kobayashi, Nashrah Zaidi, Sudha Mishra, Annu Dalal, Samanwita Mohapatra, Manish K. Yadav, Yuzuru Itoh, Rob Leurs, Andy Chevigné, , Arun K. Shukla

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

bioRxiv · Feb 1, 2024 · PreprintBiochemistry

Structural basis of streptomycin off-target binding to human mitoribosome

Yuzuru Itoh, Vivek Singh, Anas Khawaja, Andreas Naschberger, Nguyen Minh Duc, Joanna Rorbach, Alexey Amunts

This paper reports the 2.23-[A] resolution structure of the human mitoribosomal small subunit bound to streptomycin, revealing new insights into its off-target interactions.

eLife · Oct 27, 2022Peer-reviewedMolecular Biology