Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency
Daisuke Ariyasu, Emika Kubo, Daisuke Higa, Shinsuke Shibata, Yutaka Takaoka, Michihiko Sugimoto, Kazunori Imaizumi, Tomonobu Hasegawa, Kimi Araki
The paper establishes an IGHD2 mouse model to study GH deficiency, finding reduced Ghrhr and Gh promoter activities due to decreased nuclear CREB3L2 levels, revealing a novel molecular mechanism.
bioRxiv · Feb 8, 2019 · PreprintGenetics