Kimi Araki

This study identifies age-related erosion of organ-specific endothelial programs and links it to tissue dysfunction across multiple organs.

This study identifies Il1r2 as a marker for slow-cycling epidermal basal cells and develops a genetic tool for lineage tracing and IL-1 signaling modulation.

The paper shows MEIOSIN has a STRA8-independent activity that drives meiotic entry in vertebrates, with different effects in zebrafish and mice.

This study investigates the role of coilin in mice by generating coilin mutants, revealing its involvement in snRNA modifications and the formation of novel condensates in spermatids.

This study identifies MAP7 as a key regulator of microtubule remodeling in Sertoli cells, essential for apical domain formation and timely meiotic progression in mouse testes.

The paper shows that modified adenosines from RNA catabolism are sequentially metabolized to prevent toxicity and maintain metabolic balance.

This study uses CRISPR, Tocky, and machine learning to analyze Foxp3 transcription dynamics in mice, revealing CNS2-dependent regulation and age-related expression patterns.

This study identifies HSF5 as a male germ cell-specific factor critical for meiotic prophase progression beyond pachytene under non-stress conditions.

The paper shows Morc1 re-silences activated transposons in gonocytes by establishing heterochromatin, preventing their disruptive effects on the transcriptome.

The paper identifies VGF as a thalamus-derived factor essential for maintaining layer 4 neuron numbers in mouse sensory cortices, highlighting thalamocortical axons' role in shaping cortical cytoarchitecture through area-specific secretory protein supply.

This study identifies a ZFP541-KCTD19 repressor complex that promotes meiotic prophase exit in spermatogenesis by suppressing transcriptional regulators and chromatin modifiers.

This study identifies C19orf57 as a factor that modulates RAD51 and DMC1 localization to DSBs during meiotic recombination in mice, impacting DSB repair and male fertility.

The paper identifies NSUN2 as a methyltransferase that introduces 5-methylcytidine into mitochondrial tRNAs in mice and humans.

The paper establishes an IGHD2 mouse model to study GH deficiency, finding reduced Ghrhr and Gh promoter activities due to decreased nuclear CREB3L2 levels, revealing a novel molecular mechanism.

This study identifies WDR11 as a regulator of Hedgehog signaling and ciliogenesis, linking its mutations to ciliopathy and Kallmann syndrome.