Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCRβ selection
Esther Jeong Yoon Kim, Dominik A. Aylard, Zoë Steier, Daisy Ortiz, Jean Choi, Stefanie Chen, Aaron Streets, Nir Yosef, Ellen A. Robey
The paper shows preselection CD4+CD8+ thymocytes undergo gene expression changes linked to reduced TCR responsiveness and impaired CD4 fate gene upregulation, connecting these changes to T cell lineage commitment.
The Journal of Immunology · Jun 1, 2026Peer-reviewedImmunology