Author

Dominik A. Aylard

Gladstone InstitutesORCID 0000-0002-9644-2879Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Aaron StreetsiD· 2 shared Ellen A. RobeyiD· 2 shared Esther Jeong Yoon KimiD· 2 shared Nir YosefiD· 2 shared Zoë SteieriD· 2 shared Alexander J. RitteriD· 1 shared Byron B. Au‐YeungiD· 1 shared Can ErgeniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

Aaron StreetsORCID

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3 papers

Recent·Most cited

Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCRβ selection

Esther Jeong Yoon Kim, Dominik A. Aylard, Zoë Steier, Daisy Ortiz, Jean Choi, Stefanie Chen, Aaron Streets, Nir Yosef, Ellen A. Robey

The paper shows preselection CD4+CD8+ thymocytes undergo gene expression changes linked to reduced TCR responsiveness and impaired CD4 fate gene upregulation, connecting these changes to T cell lineage commitment.

The Journal of Immunology · Jun 1, 2026Peer-reviewedImmunology

Transcriptional control of central T cell tolerance by NR4A family nuclear receptors

Hailyn V. Nielsen, Letitia Yang, James L. Mueller, Alexander J. Ritter, Ryosuke Hiwa, Irina Proekt, Elze Rackaityte, Dominik A. Aylard, Mansi Gupta, Christopher D. Scharer, Mark Stuart Anderson, Byron B. Au‐Yeung, Julie Zikherman

This study identifies the role of Nr4a family nuclear receptors in transcriptional control of T cell tolerance during thymic development, showing their necessity for negative selection and anergy-like programs in self-reactive T cells.

Nature Communications · Jan 17, 2025Peer-reviewedImmunology

Single-cell multi-omic analysis of thymocyte development reveals drivers of CD4/CD8 lineage commitment

Zoë Steier, Dominik A. Aylard, Laura Lynn McIntyre, Isabel Baldwin, Esther Jeong Yoon Kim, Lydia Kay Lutes, Can Ergen, Tse-Shun Huang, Ellen A. Robey, Nir Yosef, Aaron Streets

This study uses CITE-seq to analyze thymocyte development and identifies TCR signaling waves and the TCR/calcineurin/NFAT/GATA3 axis as drivers of CD4/CD8 lineage commitment.

bioRxiv · Jul 12, 2021 · PreprintImmunology