DNA Break Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer's Disease Mouse Model
Sydney Bartman, Dakota Hunter, Lauren Gaspar, Hannah Tobias-Wallingford, Danielo Zamor, David A. Sinclair, Giuseppe Coppotelli, Jaime M. Ross
This study shows that DNA damage-induced epigenetic changes in an Alzheimer's mouse model lead to cognitive deficits and altered amyloid pathology.
bioRxiv · Oct 21, 2025 · PreprintNeuroscience