Jaime M. Ross

This paper develops an inducible mtDNA mutator mouse model to study mitochondrial dysfunction with spatial and temporal control, showing it recapitulates the original model's phenotype.

This study examines the relationship between frailty index scores and cognitive performance in mice across different ages, finding that frailty index correlates with specific behavioral and cognitive tasks.

This study shows that DNA damage-induced epigenetic changes in an Alzheimer's mouse model lead to cognitive deficits and altered amyloid pathology.

This study shows that short-term exposure to polystyrene microplastics affects cognition, immune, and metabolic markers in a sex and APOE genotype-dependent manner in mice.

This study shows mitochondrial dysfunction causes liver lipid accumulation and inflammation in mtDNA mutator mice without obesity or insulin resistance.

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.