David A. Sinclair

immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice

This study identifies DNA methylation signatures associated with frailty in mice, distinguishing age-independent and -dependent mechanisms and revealing sex-specific patterns.

Associations Between Frailty and Cognitive Outcomes Across the Lifespan of Mice

This study examines the relationship between frailty index scores and cognitive performance in mice across different ages, finding that frailty index correlates with specific behavioral and cognitive tasks.

DNA Break Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer's Disease Mouse Model

This study shows that DNA damage-induced epigenetic changes in an Alzheimer's mouse model lead to cognitive deficits and altered amyloid pathology.

Chemotherapy accelerated bone ageing is reversed by NMN

This study shows that chemotherapy-induced bone ageing in mice is reversed by NMN treatment, through mechanisms involving phosphorus homeostasis and renal protection.

Guided multi-agent AI invents highly accurate, uncertainty-aware transcriptomic aging clocks

The paper introduces K-Dense, an AI system that creates accurate transcriptomic aging clocks with uncertainty estimates, showing continuous evolution of aging signatures.

A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive Mice

This study shows that reprogramming endothelial cells in hypertensive mice with OSK factors reduces blood pressure by inhibiting EndMT and vascular damage.

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

Multiomic clocks to predict phenotypic age in mice

This paper develops a multi-omic model to predict phenotypic age in mice, showing it can predict remaining lifespan even among same-aged mice.

Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice

This study identifies sex-specific metabolite biomarkers of frailty in aging mice using longitudinal metabolomics and machine learning.

Mitochondrial Dysfunction Induces Hepatic Lipid Accumulation and Inflammatory Responses in mtDNA Mutator Mice

This study shows mitochondrial dysfunction causes liver lipid accumulation and inflammation in mtDNA mutator mice without obesity or insulin resistance.

Cellular rejuvenation protects neurons from inflammation mediated cell death.

This study identifies a senescent-like phenotype in neurons under inflammation and shows that rejuvenation improves survival in an MS model.

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila

Novel feature selection methods for construction of accurate epigenetic clocks

This paper develops novel feature selection methods to construct epigenetic clocks with high accuracy using fewer CpG sites, outperforming existing models.

TIME-Seq Enables Scalable and Inexpensive Epigenetic Age Predictions

The paper introduces TIME-Seq, a low-cost method for epigenetic age prediction, and validates it on mouse and human samples, showing improved scalability and accuracy.

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.

Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals

The paper shows that inducing DNA breaks accelerates aging-related chromatin changes and loss of cell identity in mammals.

NAD+ repletion rescues female fertility during reproductive ageing

This study shows that NAD+ repletion with NMN improves oocyte quality and fertility in aged animals, and enhances IVF success in older mice.

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.