Preclinical Evaluation of a Novel BOC-Modified Triazoloacridinone (TRA-01AR) in Combination with 5-Fluorouracil in Colorectal Cancer
Marta Switalska, Paulina Czechowicz, Magdalena Milczarek, Sylwia Bartoszewska, Beata Filip-Psurska, Katarzyna Wierzbicka, Mateusz Psurski, Damian Szczesny, Eliza Turlej, Karol Krzyminski, Malgorzata Gawronska, Magdalena Gebert, Leszek Kalinowski, David K Crossman, Maciej Baginski, , Joanna Wietrzyk
This study evaluates the combination of 5-FU with two triazoloacridinones, C-1305 and TRA-01AR, in CRC, finding that C-1305 shows greater antitumor activity while TRA-01AR has improved tolerability and vascular effects.
bioRxiv · Nov 10, 2026 · PreprintPharmacology & Toxicology