Optimizing a CRISPR-Cas13d gene circuit for tunable target RNA downregulation with minimal collateral RNA cutting
Yiming Wan, Christopher Helenek, Damiano Coraci, Gábor Balázsi
This paper develops MONARCH gene circuits to optimize CRISPR-Cas13d for tunable RNA downregulation with minimal off-target effects in human and green monkey cells.
ACS Synthetic Biology · Oct 8, 2024Peer-reviewedSynthetic Biology