Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice
Damien Freytag, Stéphane Giorgiutti, Grégoire Hopsomer, Nadège Wadier, Sabine Depauw, Philippe Mertz, Fabrice Augé, Raphaël Carapito, Isabelle Couillin, Anne‐Sophie Korganow, Francesca Pala, Marita Bosticardo, Luigi Daniele Notarangelo, Frédéric Rieux‐Laucat, Nicolas Riteau, , Pauline Soulas-Sprauel
This study identifies T cell exhaustion in STING GOF mice as driven by lymphopenia, independent of type I interferons and intrinsic STING activation.
EMBO Molecular Medicine · Aug 13, 2025Peer-reviewedImmunology