Author

Pauline Soulas-Sprauel

InsermORCID 0000-0002-2058-4811Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Abdelmnim RadouaiD· 1 shared Ameetha Ratier· 1 shared Anne‐Sophie KorganowiD· 1 shared Carmen GarridoiD· 1 shared Caroline TruntzeriD· 1 shared Cassandre Pignol· 1 shared Catherine Paul· 1 shared Christian PoüsiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

Abdelmnim RadouaORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 24, 2026

CASM potentiates STING-driven NFκB signaling in immune cells

Isis Benoit-Lizon, Cassandre Pignol, Kirsty M. Hooper…·Lionel Apétoh

The paper investigates the role of CASM in STING signaling, finding that CASM enhances NFκB-driven TNF production while autophagy exerts negative feedback on STING pathways.

DOI 10.64898/2026.01.21.700774

mouseproteomics

𝕏 PostBluesky

ImmunologyEMBO Molecular MedicinePeer-reviewedAug 13, 2025

Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice

Damien Freytag, Stéphane Giorgiutti, Grégoire Hopsomer…·Pauline Soulas-Sprauel

This study identifies T cell exhaustion in STING GOF mice as driven by lymphopenia, independent of type I interferons and intrinsic STING activation.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky