A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS
Katherine E. Irwin, Pei Jasin, Kerstin E. Braunstein, Irika R. Sinha, Kyra D. Bowden, Abhay Moghekar, Esther S. Oh, Denitza Raitcheva, Dan Bartlett, James D. Berry, Bryan J. Traynor, Jonathan P. Ling, Philip C. Wong
The paper identifies a fluid biomarker, cryptic HDGFL2, that detects early TDP-43 splicing repression in pre-symptomatic ALS patients.
bioRxiv · Jan 23, 2023 · PreprintMolecular Biology