Author

Kyra D. Bowden

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

Jonathan P. LingiD· 3 shared Irika R. SinhaiD· 2 shared Philip C. WongiD· 2 shared Rogger P. Carmen‐OrozcoiD· 2 shared Seth BlackshawiD· 2 shared Shuying SuniD· 2 shared Vickie TrinhiD· 2 shared Abhay MoghekariD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Jonathan P. LingORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Elevated nuclear TDP-43 induces constitutive exon skipping

Rogger P. Carmen‐Orozco, William Tsao, Yingzhi Ye, Irika R. Sinha, Koping Chang, Vickie Trinh, William Chung, Kyra D. Bowden, Juan Carlos Troncoso, Seth Blackshaw, Lindsey R. Hayes, Shuying Sun, Philip C. Wong, Jonathan P. Ling

This study shows that elevated nuclear TDP-43 causes species-specific exon skipping, which differs from exon skipping seen in TDP-43 loss-of-function, highlighting the need for careful interpretation of TDP-43 overexpression models.

Molecular Neurodegeneration · Jun 9, 2024Peer-reviewedNeuroscience

A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS

Katherine E. Irwin, Pei Jasin, Kerstin E. Braunstein, Irika R. Sinha, Kyra D. Bowden, Abhay Moghekar, Esther S. Oh, Denitza Raitcheva, Dan Bartlett, James D. Berry, Bryan J. Traynor, Jonathan P. Ling, Philip C. Wong

The paper identifies a fluid biomarker, cryptic HDGFL2, that detects early TDP-43 splicing repression in pre-symptomatic ALS patients.

bioRxiv · Jan 23, 2023 · PreprintMolecular Biology

Cell-specific regulation of gene expression using splicing-dependent frameshifting.

Jonathan P. Ling, Alexei M. Bygrave, Clayton P. Santiago, Rogger P. Carmen‐Orozco, Vickie Trinh, Minzhong Yu, Yini Li, Ying Liu, Kyra D. Bowden, Leighton H. Duncan, Jeong Soon Han, Kamil Taneja, Rochinelle Dongmo, Travis A. Babola, Patrick Parker, , Seth Blackshaw

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.

Nature Communications · Oct 1, 2022Peer-reviewedMolecular Biology