Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response
Long-Feng Lu, Can Zhang, Zhuo-Cong Li, Bao-Jie Cui, Yang-Yang Wang, Ke-Jia Han, Xiao Xu, Chu-Jing Zhou, Xiao-Yu Zhou, Yue Wu, Na Xu, Yang Xu, Dan-Dan Chen, Xiyin Li, Li Zhou, Shun Li
This study shows that fish CDK2 recruits Dtx4 to ubiquitinate and degrade TBK1, reducing IFN expression and enhancing antiviral resistance.
eLife · Jul 24, 2024Peer-reviewedImmunology