Li Zhou

This study identifies MARCHF8 as a driver of cancer immune evasion by degrading MHC-I proteins and shows its inhibition enhances antitumor immunity and response to immunotherapy.

This study identifies cyp17a2 as a male-biased gene that enhances antiviral immunity in zebrafish by stabilizing STING and degrading viral proteins.

This study shows that fish CDK2 recruits Dtx4 to ubiquitinate and degrade TBK1, reducing IFN expression and enhancing antiviral resistance.

HS-OmicsDB aggregates bulk and single-cell RNA sequencing data from untreated HS patients to profile gene expression in specific tissue types and map cell-specific gene expression in HS lesions.